Advice on opening large/huge files

From time to time, I need to edit large files (~10^2-10^3 MB).
In my tests, Vim loads large files relatively quickly (~100MB/s).
It's (some) filetype plugins that hog Vim.

For instance, take any large file and change its suffix to have
it recognized as Markdown. After Vim has read it (you'll see
the line/char count in the command line), it gets stuck.

I have tried the LargeFile plugin, but I haven't noticed any
difference.

Any suggestions?

Thanks,
Life.

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